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Transfersomes and Protransfersome: Ultradeformable Vesicular System
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Author(s): Bhushan Rajendra Rane (P. S. G. V. P. Mandal's College of Pharmacy, India)and Nayan Ashok Gujarathi (P. S. G. V. P. Mandal's College of Pharmacy, India)
Copyright: 2017
Pages: 21
Source title:
Novel Approaches for Drug Delivery
Source Author(s)/Editor(s): Raj K. Keservani (Rajiv Gandhi Proudyogiki Vishwavidyalaya, India), Anil K. Sharma (GD Goenka University, India)and Rajesh Kumar Kesharwani (National Institute of Technology, Warangal, India)
DOI: 10.4018/978-1-5225-0751-2.ch006
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Abstract
Vesicular system brings several possible advantages over conventional route of drug delivery system. Formulation of system to administered via transdermal is an attractive option because this route is suitable and safe. Transfersomes is one of vesicular system which possesses a single chain surfactant as it offers ultra deformation property which provides better penetration. Vesicles of hydrophobic and hydrophilic moieties can be formulated together and as a result can deliver drug molecules with wide range of solubility. Problems of drug leakage and low entrapment could be overcome in this system. Materials which are widely used in the formulation of it are various phospholipids, surfactants, alcohol, dye and buffering agent. These systems can deform up to 5 times lesser than its original size to pass through narrow constriction without showing drug leakage. These are more flexible and adjustable than that of liposomes thus can be used to carry drugs across the biological membrane, such as skin. It can act as a carrier for wide variety of drugs.
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