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Bisphenol A and Phthalates Exhibit Similar Toxicogenomics and Health Effects
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Author(s): Sumaya Hassan (University of Kashmir, India), Rohaya Ali (University of Kashmir, India), Durdana Shah (University of Kashmir, India), Nasreena Sajjad (University of Kashmir, India)and Jasfeeda Qadir (University of Kashmir, India)
Copyright: 2020
Pages: 25
Source title:
Handbook of Research on Environmental and Human Health Impacts of Plastic Pollution
Source Author(s)/Editor(s): Khursheed Ahmad Wani (Government Degree College Bijbehara, India), Lutfah Ariana (Indonesian Institute of Sciences, Indonesia)and S.M. Zuber (Government Degree College Bijbehara, India)
DOI: 10.4018/978-1-5225-9452-9.ch014
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Abstract
Bisphenol A and phthalates are most frequently detected organic pollutants found in our surroundings because of their regular use as plasticizers in daily use polymeric products. BPA is used in manufacturing baby feeding bottles, water pipes, canned food linings, and food packaging materials. Phthalates are used in polyvinyl chloride products including clothing, toys, medical devices, and food packaging. These chemicals are not bound to the matrix and leach out into the surroundings on slight change in the environment, like alteration in pH, temperature, and pressure. Humans are continuously exposed to these chemicals through skin contact, inhalation, or ingestion when the leachates enter food, drinks, air, water, or soil. The Comparative Toxicogenomics Database (CTD) revealed that Bisphenol A has 1932 interactions with genes/proteins and few frequently used phthalates (DEHP, MEHP, DBP, BBP, and MBP) showed 484 gene/protein interactions. Similar toxicogenomics and adverse effects of Bisphenol A and phthalates on human health are attributed to their 89 common interacting genes/proteins.
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