IRMA-International.org: Creator of Knowledge
Information Resources Management Association
Advancing the Concepts & Practices of Information Resources Management in Modern Organizations

Cancer Drug Delivery: Pharmacogenetics, Biomarkers, and Targeted Therapies

Cancer Drug Delivery: Pharmacogenetics, Biomarkers, and Targeted Therapies
View Sample PDF
Author(s): Jai N. Patel (Levine Cancer Institute, USA)and Jeryl Villadolid (Levine Cancer Institute, USA)
Copyright: 2017
Pages: 44
Source title: Pharmaceutical Sciences: Breakthroughs in Research and Practice
Source Author(s)/Editor(s): Information Resources Management Association (USA)
DOI: 10.4018/978-1-5225-1762-7.ch008

Purchase

View Cancer Drug Delivery: Pharmacogenetics, Biomarkers, and Targeted Therapies on the publisher's website for pricing and purchasing information.

Abstract

Advancements in cancer drug delivery have led to the development of personalized oncology care through molecularly-driven targeted therapies. Understanding molecular and cellular mechanisms which drive tumor progression and resistance is critical in managing new treatment strategies which have shifted from empiric to biomarker-directed therapy selection. Biomarker-directed therapies have improved clinical outcomes in multiple malignancies as monotherapy and in combination with other treatment modalities, however the changing scope of treatment options presents new opportunities and challenges for research. Furthermore, pharmacogenetics may provide a rationale method of personalizing anticancer drug dosing and supportive care management for oncology patients. This chapter reviews biomarker classifications and pharmacogenetics in anticancer therapy and supportive care. Examples of biomarker-directed therapies and clinical assays, in addition to future directions of molecular profiling in oncology therapy management are discussed.

Related Content

Abul Kalam Azad, Mohamad Dayoob, Fatema Tuz Zohera. © 2024. 21 pages.
W. H. P. A. D. Perera, Mithuni N. Senadeera, Dinusha N. Udukala. © 2024. 26 pages.
Thi Van Anh Nguyen, Trang Nguyen Ngoc, Thanh Tung Bui. © 2024. 43 pages.
Abul Kalam Azad, Mallari Praveen, Wan Mohd Azizi Bin Wan Sulaiman. © 2024. 31 pages.
Bancha Yingngam. © 2024. 43 pages.
Babi Lakkoju, Swapna Asuthkar, Gundla Rambabu, Kolli Balakrishna. © 2024. 20 pages.
Arthi Gunasekaran, Trisha Sathya, Vijaya Anand Arumugam, Balamuralikrishnan Balasubramanian, Asirvatham Alwin Robert, Arun Meyyazhagan. © 2024. 31 pages.
Body Bottom