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HIV-Associated Neurocognitive Disorder: The Interaction Between HIV-1 and Dopamine Transporter Structure

HIV-Associated Neurocognitive Disorder: The Interaction Between HIV-1 and Dopamine Transporter Structure
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Author(s): Ahmed Abd Elkader Elrashedy (National Research Center, Egypt)
Copyright: 2018
Pages: 35
Source title: Big Data Analytics in HIV/AIDS Research
Source Author(s)/Editor(s): Ali Al Mazari (Alfaisal University, Saudi Arabia)
DOI: 10.4018/978-1-5225-3203-3.ch008

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Abstract

In the last two decades, several advancement studies have increased the care of HIV-infected individuals. Specifically, the development for preparation of combination antiretroviral therapy has resulted in a dramatic decline in the rate of deaths from AIDS. The term “HIV-associated neurocognitive disorder” (HAND) has been used to distinguish the spectrum of neurocognitive dysfunction associated with HIV infection. HIV can pass to the CNS during the early stages of infection and last in the CNS. CNS inflammation and infection lead to the development of HAND. The brain can serve as a sanctuary for ongoing HIV replication, even when the systemic viral suppression has been achieved. HAND can remain in patients treated with combination antiretroviral therapy, and its effect on survival, quality of life, and everyday functioning make it a significant unresolved problem. This chapter discusses details of the computational modeling studies on mechanisms and structures of human dopamine transporter (hDAT) and its interaction with HIV-1 trans activator of transcription (Tat).

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