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New Herbal Approaches for the Treatment of Diabetic Kidney Diseases and Its Therapeutic Implications

New Herbal Approaches for the Treatment of Diabetic Kidney Diseases and Its Therapeutic Implications
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Author(s): Durgavati Yadav (Institute of Medical Sciences, India), Vivek Pandey (Institute of Medical Science, India), Shivani Srivastava (Institute of Medical Sciences, India) and Yamini Bhusan Tripathi (Institute of Medical Science, India)
Copyright: 2017
Pages: 39
Source title: Recent Advances in Drug Delivery Technology
Source Author(s)/Editor(s): Raj K. Keservani (Rajiv Gandhi Proudyogiki Vishwavidyalaya, India), Anil K. Sharma (GD Goenka University, India) and Rajesh Kumar Kesharwani (National Institute of Technology, Warangal, India)
DOI: 10.4018/978-1-5225-0754-3.ch013

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Abstract

Diabetic Kidney Diseases (DKD) is a very serious complication of diabetes. There is recent steep rise in the prevalence of metabolic syndrome and DKD worldwide. Factors responsible for intraglomerular hypertension include activation of various vasoactive systems, polyol pathway, oxidative stress, inflammation and protein kinase C. Sodium-Dependent Glucose Co-Transporter (SGLT-2) inhibitors, DPP-IV (Dipeptidyl peptidase-4) inhibitors are being develop to manage the hyperglycemia and oxidative stress induced inflammatory cascade. Herbal drugs have gained increasing popularity; are complex mixtures of polyphenols and phytochemicals from any raw or processed part of a plant, including leaves. Herbal drugs in this modern era are preferred due to its lesser side effects. Various preparations are presently used for ameliorating the effect of DKD. Since, medicinal plants have been reported to affect various metabolic receptors, enzymes and signaling cascade. Above book chapter explains the involvement of different phytochemicals in biological pathway associated with the kidney damage.

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