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Precision Medicine in Cancer

Precision Medicine in Cancer
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Author(s): Nerethika Ravichandiran (Department of Bio-Medical Science, Bharathidasan University, India), Muneesh Kumar Barman (Laboratory for HIV Research, National Centre for Cell Sciences, Pune, India), Sai Tejaswi Lavuri (Chalmeda Anand Rao College of Medical Sciences, KNR University of Health Sciences, India), Manjita Srivastava (National Institute of Virology (ICMR), India), Shalini Sakthivel (Department of Bio-Medical Science, Bharathidasan University, India), Meenakshi Singh (Transplant Immunology and Immunogenetics Lab (HLA), ACTREC, Tata Memorial Centre, India), Kailash Chand (National Centre for Cell Sciences, Pune, India), Subash C. Sonkar (Multidisciplinary Research Unit, Department of Biochemistry, New Delhi, India) and Prudhvilal Bhukya (National Institute of Virology (ICMR), Pune, India)
Copyright: 2021
Pages: 34
Source title: Handbook of Research on Advancements in Cancer Therapeutics
Source Author(s)/Editor(s): Sumit Kumar (National Institute of Pathology, New Delhi, India), Moshahid Alam Rizvi (Jamia Millia Islamia, India) and Saurabh Verma (National Institute of Pathology, India)
DOI: 10.4018/978-1-7998-6530-8.ch015

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Abstract

Cancer is the one of the deadliest diseases and takes the lives of millions of people every year across the world. Due to disease heterogeneity and multi-factorial reasons, traditional treatment such as radiation therapy, immunotherapy, or chemotherapy are effective only among a small population of the patients. Tumors can have different fundamental genetic causes and protein expressions that differ from one patient to another. This variability among individual lends itself to the field of precision and personalized medicine. Following the completion of human genome sequencing, significant progress has been observed in the characterization of human epigenome, proteome, and metabolome. Pharmacogenetics and pharmacogenomics use this sequence to study the genetic causes of individual variations in drug response and the simultaneous impact of change in genome that decide the patient's response to drug respectively. On summation, identify the subpopulation of patient and provide them tailored therapy thus increasing the effectiveness of treatment. All these evolved the field of precision or personalized medicine that plays a crucial role in cancer prevention, prognosis, diagnosis, and therapeutics. These tailored therapies are characterized by increased efficiency and reduced toxicity. Not all cancers have genetic variability; some are also influenced by polymorphism of gene encoding enzymes that play an important role in pharmacokinetics of drug. The discoveries of cancer predisposition genes allow diagnosis of a patient at risk of cancer development and let them make the decision on précised individual risk modification characteristic. The use of CYP2D6 genotyping for breast cancer, mutation in KRAS in colorectal cancer, genomic variation in EGFR in small lung cancer, melanoma are some of the examples of importance of cancer predisposition genes. In recent times, distinct molecular subtypes of cancers have been identified with requirement of different treatment for each subtype. Precision medicine shifts the trend from reaction to prevention and forestalls disease progression.

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