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Therapeutic Approaches to Employ Monoclonal Antibody for Cancer Treatment

Therapeutic Approaches to Employ Monoclonal Antibody for Cancer Treatment
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Author(s): Salonee Martins (National Institute of Virology (ICMR), India), Purva Salvi (National Institute of Virology (ICMR), India), Sai Tejaswi Lavuri (Chalmeda Anand Rao College of Medical Sciences, KNR University of Health Sciences, India), Manjita Srivastava (National Institute of Virology (ICMR), India), Shalini Sakthivel (Department of Bio-Medical Science, Bharathidasan University, India), Muneesh Kumar Barman (Laboratory for HIV Research, National Centre for Cell Sciences, Pune, India), Kailash Chand (National Centre for Cell Sciences, Pune, India), Meenakshi Singh (Transplant Immunology and Immunogenetics Lab (HLA), ACTREC, Tata Memorial Centre, India), Subash C. Sonkar (Multidisciplinary Research Unit, Department of Biochemistry, New Delhi, India) and Prudhvilal Bhukya (National Institute of Virology (ICMR), Pune, India)
Copyright: 2021
Pages: 47
Source title: Handbook of Research on Advancements in Cancer Therapeutics
Source Author(s)/Editor(s): Sumit Kumar (National Institute of Pathology, New Delhi, India), Moshahid Alam Rizvi (Jamia Millia Islamia, India) and Saurabh Verma (National Institute of Pathology, India)
DOI: 10.4018/978-1-7998-6530-8.ch002


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With the evolution of the tissue system and division of function among differentiated cells/tissues, the property of controlled cell growth also evolved in animals. It is when this very control is lost that cancers develop. The immune system's ability to distinguish between self and non-self is central to impeding cancer progression. However, cancer cells in time can develop multiple ways of escaping immune control. Even today, cancer remains a disease of baffling complexity on account of its diverse origin and pathogenesis. Classical methods like surgery, radiation, and chemotherapy have failed to make the cut as idyllic therapy, especially considering the encumbering side-effects and high failure rate. Alternative therapeutic strategies that exploit the immune system itself have proved promising. One of these is monoclonal antibody therapy. In this chapter, the relationship between the immune system and cancer and various forms of immunotherapy are discussed in detail.

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