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Application of Nanoparticles as a Drug Delivery System
Abstract
Small colloidal particles having their diameter in the range of 50 to 500nm are defined as Nanoparticles. These are usually prepared either by using biodegradable or non-biodegradable polymers and are usually classified in two broad categories: (1) Nanocapsules: a type of reservoir system in which an oil or aqueous core is surrounded by a polymeric membrane. (2) Nanospheres: a type of matrix system. Preparation of nanoparticle as a drug delivery system is one of the most widely accepted approach since the prepration of nanoparticle were easy and convenient to scale up. Their high stability and conveniently easy to freeze-dried their preparations provide some additional advantages to choose Nanoparticles as a good drug delivery system. Inspite of them Nanoparticles were were able to achieve with success tissue targeting of many drugs (antibiotics, cytostatics, peptides and proteins, nucleic acids, etc.).
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