The IRMA Community
Newsletters
Research IRM
Click a keyword to search titles using our InfoSci-OnDemand powered search:
|
Dynamical Analysis of Drug Efficacy and Mechanism of Action Using GFP Reporters
|
|
Author(s): Jianping Hua (Texas A&M University, USA), Chao Sima (Texas A&M University, USA), Milana Cypert (Texas A&M University, USA), Edward R. Dougherty (Texas A&M University, USA), Jeffery M. Trent (Translational Genomics Research Institute, USA)and Michael L. Bittner (Translational Genomics Research Institute, USA)
Copyright: 2017
Pages: 30
Source title:
Biometrics: Concepts, Methodologies, Tools, and Applications
Source Author(s)/Editor(s): Information Resources Management Association (USA)
DOI: 10.4018/978-1-5225-0983-7.ch045
Purchase
|
Abstract
To the development of effective cancer drug, it is necessary to, first, identify drugs and their possible combinations that could exert desired control over the type of cancer being considered; second, have a drug testing method that allows one to assess the variety of responses that can be provoked by drugs. To facilitate such an experiment-modeling-experiment cycle for drug development, a method based on the dynamical systems of pathways is presented. It involves a three-state experimental design: (1) formulate an oncologic pathway model of relevant cancer; (2) perturb the pathways with the drugs of known effects on components of the pathways of interest; and (3) measure process activity indicators at various points on cell populations. To evaluate the drug response in a high-throughput manner, a green fluorescent protein reporter-based technology has been developed. The authors apply the dynamical approach to several issues in the context of colon cancer cell lines.
Related Content
|
Ajay Rawat, Shivani Gambhir.
© 2017.
19 pages.
|
|
Abhijit Chandra, Srideep Maity.
© 2017.
15 pages.
|
|
Swanirbhar Majumder, Saurabh Pal.
© 2017.
26 pages.
|
|
Fouad Farouk Jabri.
© 2017.
32 pages.
|
|
Francisco Pacheco Andrade, Teresa Coelho Moreira.
© 2017.
13 pages.
|
|
Swanirbhar Majumder, Smita Majumder.
© 2017.
31 pages.
|
|
Yuanfang Guo, Oscar C. Au, Ketan Tang.
© 2017.
20 pages.
|
|
|