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Rational Design of Polymeric Micelle for Cancer Therapy
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Author(s): Yixian Huang (University of Pittsburgh, USA), Jingjing Sun (University of Pittsburgh, USA)and Song Li (University of Pittsburgh, USA)
Copyright: 2017
Pages: 26
Source title:
Novel Approaches for Drug Delivery
Source Author(s)/Editor(s): Raj K. Keservani (Rajiv Gandhi Proudyogiki Vishwavidyalaya, India), Anil K. Sharma (GD Goenka University, India)and Rajesh Kumar Kesharwani (National Institute of Technology, Warangal, India)
DOI: 10.4018/978-1-5225-0751-2.ch012
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Abstract
Clinical application of anticancer drugs is limited by problems such as low water solubility, lack of tissue-specificity and toxicity. Formulation development represents an important approach to these problems. Among the many delivery systems studied, polymeric micelles are an attractive nano-scaled delivery system due to their simplicity, ability to solubilize water-insoluble drugs, and small size (10-100 nm) that can take advantage of enhanced permeability and retention effect to specifically accumulate in tumors. This book chapter provides a brief review of recent advancements in developing environmentally responsive micellar systems for controlled delivery of chemotherapeutic agents to tumor tissues. The emphasis is placed on the discussion of several dual functional nanomicellar systems that were recently developed in our laboratory as well as a new strategy of improving micellar formulations via incorporation of an interfacial drug-interactive motif(s).
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