The IRMA Community
Newsletters
Research IRM
Click a keyword to search titles using our InfoSci-OnDemand powered search:
|
In Silico Recognition of Protein-Protein Interaction: Theory and Applications
|
Author(s): Byung-Hoon Park (Oak Ridge National Laboratory, USA), Phuongan Dam (University of Georgia, USA), Chongle Pan (University of Tennessee, USA), Ying Xu (University of Tennessee, USA), Al Geist (Oak Ridge National Laboratory, USA), Grant Heffelfinger (Sandia National Laboratories, USA)and Nagiza F. Samatova (Oak Ridge National Laboratory, USA)
Copyright: 2006
Pages: 21
Source title:
Advanced Data Mining Technologies in Bioinformatics
Source Author(s)/Editor(s): Hui-Huang Hsu (Tamkang University, Taipei, Taiwan)
DOI: 10.4018/978-1-59140-863-5.ch013
Purchase
|
Abstract
Protein-protein interactions are fundamental to cellular processes. They are responsible for phenomena like DNA replication, gene transcription, protein translation, regulation of metabolic pathways, immunologic recognition, signal transduction, etc. The identification of interacting proteins is therefore an important prerequisite step in understanding their physiological functions. Due to the invaluable importance to various biophysical activities, reliable computational methods to infer protein-protein interactions from either structural or genome sequences are in heavy demand lately. Successful predictions, for instance, will facilitate a drug design process and the reconstruction of metabolic or regulatory networks. In this chapter, we review: (a) high-throughput experimental methods for identification of protein-protein interactions, (b) existing databases of protein-protein interactions, (c) computational approaches to predicting protein-protein interactions at both residue and protein levels, (d) various statistical and machine learning techniques to model protein-protein interactions, and (e) applications of protein-protein interactions in predicting protein functions. We also discuss intrinsic drawbacks of the existing approaches and future research directions.
Related Content
Linkon Chowdhury, Md Sarwar Kamal, Shamim H. Ripon, Sazia Parvin, Omar Khadeer Hussain, Amira Ashour, Bristy Roy Chowdhury.
© 2024.
20 pages.
|
Mousomi Roy.
© 2024.
21 pages.
|
Nassima Dif, Zakaria Elberrichi.
© 2024.
20 pages.
|
Pyingkodi Maran, Shanthi S., Thenmozhi K., Hemalatha D., Nanthini K..
© 2024.
16 pages.
|
Mohamed Nadjib Boufenara, Mahmoud Boufaida, Mohamed Lamine Berkane.
© 2024.
16 pages.
|
Meroua Daoudi, Souham Meshoul, Samia Boucherkha.
© 2024.
25 pages.
|
Zhongyu Lu, Qiang Xu, Murad Al-Rajab, Lamogha Chiazor.
© 2024.
56 pages.
|
|
|