The IRMA Community
Newsletters
Research IRM
Click a keyword to search titles using our InfoSci-OnDemand powered search:
|
A Phylogenetic Approach to the Uneven Global Distribution of the COVID-19 Pandemic: Y-Chromosomal Haplogroups and COVID-19 Mortality
Abstract
A possible role of Y chromosomal haplogroups in COVID-19 mortality is discussed without claiming causality. The mortality of COVID-19 seems unequally distributed in different populations and statistically significant regional covariation is presented between COVID-19 mortality and the haplogroup Y-R1b. Y-R1b is suggested as a possible marker for mortality in the first wave of the pandemic affecting the Western Europe. September 2020 the pandemic involved also Eastern Europe severely in a second wave, while South East Asia, with a very high frequency of Y-0, had strikingly low COVID-19 mortality rate. Eastern Europe is dominated by Y-haplogroups (i.e., Y-R1a), with close ancestry to Y-R1b. Molecular mechanisms mediated by the Y chromosome involved in COVID-19 mortality are discussed, presenting a possible role of KDM5D in androgen receptor modulation and regulation of TMPRSS2 known to enable SARS-CoV-2 binding to ACE2 and facilitating virus entrance into the cell and virus replication. Sex bias and comorbidities point at the role of variations in the Y-chromosomal phylogeny.
Related Content
|
Tebeje Molla.
© 2024.
16 pages.
|
|
Ruth Vilà Baños, Angelina Sánchez Martí, Montse Freixa Niella, Marta Venceslao Pueyo.
© 2024.
17 pages.
|
|
Icarbord Tshabangu, Minenhele Moyo.
© 2024.
15 pages.
|
|
F. Javier García Castaño, Marta Zornoa Madrid, Lucía Lerma Parra, Carla Alba Pulido.
© 2024.
28 pages.
|
|
Sara Mohammed Aldous, Ghaith Ahmed Ismail.
© 2024.
22 pages.
|
|
Meritxell Argelagués, Miquel Àngel Essomba, Anna Tarrés, Maria Nadeu.
© 2024.
17 pages.
|
|
Adiela Ruiz-Cabezas, Ana Isabel Holgueras González, María del Castañar Medina Domínguez.
© 2024.
18 pages.
|
|
|