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Analysis of the Bacterial Vesicles' Enhanced Toxicological Threat Via Electron Microscopy
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Author(s): Roberta Curia (University of Milano-Bicocca, Italy), Marziale Milani (University of Milano-Bicocca, Italy), Lyubov V. Didenko (Gamaleya Research Institute for Epidemiology and Microbiology, Russia), George A. Avtandilov (Moscow State University of Medicine and Dentistry, Russia), Natalia V. Shevlyagina (Gamaleya Research Institute for Epidemiology and Microbiology, Russia)and Francesco Tatti (FEI Company, Italy)
Copyright: 2017
Pages: 25
Source title:
Advancing Medicine through Nanotechnology and Nanomechanics Applications
Source Author(s)/Editor(s): Keka Talukdar (Nadiha High School, India), Mayank Bhushan (Pondicherry University, India)and Anil Shantappa Malipatil (Guru Nanak Dev Engineering College – Bidar, India)
DOI: 10.4018/978-1-5225-1043-7.ch002
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Abstract
This study shows the importance of electron microscopy in the analysis of the interaction of microorganisms (Staphylococcus aureus) with polymeric (polyurethane) dental prostheses. Starting from the biofilm formation and the biodestruction of the plastic material resulting in the production of polyurethane nanoparticles, the focus is on the bacterial secretion of membrane vesicles (in the range of 20-50 nm) loaded with plastic nanoparticles (from 2-3 to 10 nm) and on the toxicological threat that these delivery devices represent when interacting with host cells. The nanoparticles deliverance led by the bacterial infections dynamics opens new ways to the possibility of delivering drugs to selected cells.
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