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Applications of Metabolic Flux Balancing in Medicine

Applications of Metabolic Flux Balancing in Medicine
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Author(s): Ferda Mavituna (The University of Manchester, UK), Raul Munoz-Hernandez (The University of Manchester, UK) and Ana Katerine de Carvalho Lima Lobato (Federal University of Rio Grande do Norte, Brazil and Potiguar University, Brazil)
Copyright: 2009
Pages: 17
Source title: Handbook of Research on Systems Biology Applications in Medicine
Source Author(s)/Editor(s): Andriani Daskalaki (Max Planck Institute for Molecular Genetics, Germany)
DOI: 10.4018/978-1-60566-076-9.ch027

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Abstract

This chapter summarizes the fundamentals of metabolic flux balancing as a computational tool of metabolic engineering and systems biology. It also presents examples from the literature for its applications in medicine. These examples involve mainly liver metabolism and antibiotic production. Metabolic flux balancing is a computational method for the determination of metabolic pathway fluxes through a stoichiometric model of the cellular pathways, using mass balances for intracellular metabolites. It is a powerful tool to study metabolism under normal and abnormal conditions with a view to engineer the metabolism. Its extended potential in medicine is emphasized in the future trends.

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