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Cardiac Remodeling Under Hyperoxic Conditions: Hyperoxia and Heart Diseases
Abstract
Cardiovascular complications and arrhythmias account for high mortality in cardiopulmonary patients in intensive care unites (ICU) and critical care unites. Patients in ICU are often administered with 100% oxygen for treatment with many diseases. According to American Heart Association (AHA), more than 2200 deaths related to cardiac failure are reported every day with an average of 1 in every 39 seconds. Cardiomyopathy is also reported in many diseased conditions including acute lung injury, diabetes, obesity, hypertension, and cancer. Recent studies indicate that hyperoxia induces cardiac injury due to dysfunctional lung and compromised pulmonary functioning. The exact mechanism of cardiovascular complications in ICU/ critical care remains unknown. This review will discuss the effect of hyeproxia on cardiac remodeling with more emphasis on ventricular and electrical remodeling. Understanding the exact mechanism of hyperoxia induced cardiomyopathy is not only important to understand the disease development and progression but also open new avenues for targeted therapy.
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