Diagnostic Approach to Myeloid Neoplasms With Predominantly Ineffective Hematopoiesis: AML, MDS, and MDS/MPNs

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Copyright: 2024
Pages: 65
Source title: Principles and Approaches to Diagnostic Bone Marrow Examination
Source Author(s)/Editor(s): Samia Hassan Rizk (Cairo University, Egypt)
DOI: 10.4018/978-1-6684-5818-1.ch009

Keywords: Medical Diagnosis and Practice / Medical Information Science Reference / Medical Treatment & Care / Medicine & Healthcare

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Abstract

Acute myeloid leukemia, myelodysplastic syndromes, and myelodysplastic/ myeloproliferative neoplasms share pathophysiologic features of decreased/deregulated myeloid maturation. Their diagnosis relies upon peripheral blood, bone marrow morphology, extended flow cytometry panels, detailed cytogenetic and molecular analysis tailored for each subtype, possible predisposing factors, and mimicking conditions. The overall genomic analysis provides a tool for refining risk stratification and selecting novel therapies.

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Diagnostic Approach to Myeloid Neoplasms With Predominantly Ineffective Hematopoiesis: AML, MDS, and MDS/MPNs

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