Examining the Effect of Mitochondrial Fission and Fusion Events on the Heart: Role of the Mitochondria in Heart Disease

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Author(s): Ashim Malhotra (Pacific University, USA)and Shivani Soni (California State University, Fullerton, USA & Chapman University, USA & Alabama State University, USA)
Copyright: 2017
Pages: 20
Source title: Emerging Applications, Perspectives, and Discoveries in Cardiovascular Research
Source Author(s)/Editor(s): Ashim Malhotra (Pacific University, USA)and Shivani Soni (California State University, Fullerton, USA & Chapman University, USA & Alabama State University, USA)
DOI: 10.4018/978-1-5225-2092-4.ch005

Keywords: Cardiovascular Medicine / Medical Diagnosis and Practice / Medical Information Science Reference / Medicine & Healthcare

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Abstract

Mitochondria constitute an integral structural and functional part of the cardiac muscle. The heart muscle relies on the mitochondrial production of fatty acids and ATP as sources of energy during different stages of human growth and development. New mitochondria are created from existing ones by a process called mitochondrial biogenesis which involves both fusion and fission events controlled by a bevy of proteins such as Drp1, OPA1, Mfn1, and Mfn2. In this chapter, we examine the role of these mitochondrial fission and fusion proteins in regulating various heart diseases, particularly, reperfusion injury, dilated cardiomyopathy, and heart failure. It is our intent to examine whether any of these proteins may serve as future candidates for cardiovascular therapy.

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Examining the Effect of Mitochondrial Fission and Fusion Events on the Heart: Role of the Mitochondria in Heart Disease

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