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The Important Role of Lipids in Cognitive Impairment
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Author(s): Jia Yu (Peking University, China & Beijing Geriatric Hospital, China), Zheng Chen (Beijing Geriatric Hospital, China), Jiangyang Lu (First Affiliated Hospital of General Hospital of PLA, China), Tingting Liu (Peking University, China), Liang Zhou (Peking University, China), Xinying Liu (Peking University, China), Miao Sun (Peking University, China), Weizhong Xiao (Third Hospital of Peking University, China), Dongsheng Fan (Third Hospital of Peking University, China)and Dehua Chui (Peking University, China & Third Hospital of Peking University, China)
Copyright: 2013
Pages: 5
Source title:
Bioinformatics: Concepts, Methodologies, Tools, and Applications
Source Author(s)/Editor(s): Information Resources Management Association (USA)
DOI: 10.4018/978-1-4666-3604-0.ch014
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Abstract
The current knowledge base on circulating serum and plasma risk factors of the cognitive decline of degenerative Alzheimer’s Disease is linked to cholesterol homeostasis and lipoprotein disturbances (i.e., total cholesterol, 24S-hydroxy-cholesterol, lipoprotein(a), or apolipoprotein E. Lipoprotein lipase (LPL) is also expressed in the brain, with the highest levels found in the pyramidal cells of the hippocampus, suggesting a possible role for LPL in the regulation of cognitive function. Little is currently known, however, about the specific role of LPL in the brain. The authors of this chapter have generated an LPL-deficient mouse model that was rescued from neonatal lethality by somatic gene transfer. The levels of the presynaptic marker synaptophysin were reduced in the hippocampus while the levels of the post-synaptic marker PSD-95 remained unchanged in the LPL-deficient mice. The decreased frequency of mEPSC in LPL-deficient neurons indicated that the number of presynaptic vesicles was decreased, which was consistent with the decreases observed in the numbers of total vesicles and docking vesicles. These findings indicate that LPL plays an important role in learning and memory function, possibly by influencing presynaptic function.
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