The IRMA Community
Newsletters
Research IRM
Click a keyword to search titles using our InfoSci-OnDemand powered search:
|
In Machina Systems for the Rational De Novo Peptide Design
Abstract
Peptides fulfill many tasks in controlling and regulating cellular functions and are key molecules in systems biology. There is a great demand in science and industry for a fast search of innovative peptide structures. In this chapter we introduce a combination of a computer-based guided search of novel peptides in sequence space with their biological experimental validation. The computer-based search uses an evolutionary algorithm that includes artificial neural networks as fitness function and a mutation operator, called the PepHarvester. Optimization occurs during 100 iterations. This system, called DARWINIZER, is applied in the de novo design of neutralizing peptides against autoantibodies from DCM (dilatative cardiomyopathy) patients. Another approach is the optimization of peptide sequences by an ant colony optimization process. This biologically-oriented system identified several novel weak binding T-cell epitopes.
Related Content
|
David Edson Ribeiro, Valter Augusto de Freitas Barbosa, Clarisse Lins de Lima, Ricardo Emmanuel de Souza, Wellington Pinheiro dos Santos.
© 2021.
15 pages.
|
|
Juliana Carneiro Gomes, Maíra Araújo de Santana, Clarisse Lins de Lima, Ricardo Emmanuel de Souza, Wellington Pinheiro dos Santos.
© 2021.
12 pages.
|
|
Maíra Araújo de Santana, Jessiane Mônica Silva Pereira, Clarisse Lins de Lima, Maria Beatriz Jacinto de Almeida, José Filipe Silva de Andrade, Thifany Ketuli Silva de Souza, Rita de Cássia Fernandes de Lima, Wellington Pinheiro dos Santos.
© 2021.
19 pages.
|
|
Jessiane Mônica Silva Pereira, Maíra Araújo de Santana, Clarisse Lins de Lima, Rita de Cássia Fernandes de Lima, Sidney Marlon Lopes de Lima, Wellington Pinheiro dos Santos.
© 2021.
25 pages.
|
|
Adriel dos Santos Araujo, Roger Resmini, Maira Beatriz Hernandez Moran, Milena Henriques de Sousa Issa, Aura Conci.
© 2021.
35 pages.
|
|
Abir Baâzaoui, Walid Barhoumi.
© 2021.
21 pages.
|
|
Marcus Costa de Araújo, Luciete Alves Bezerra, Kamila Fernanda Ferreira da Cunha Queiroz, Nadja A. Espíndola, Ladjane Coelho dos Santos, Francisco George S. Santos, Rita de Cássia Fernandes de Lima.
© 2021.
44 pages.
|
|
|