Mature B Cell Lymphoproliferation and Lymphomas: Diagnostic Approach

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Copyright: 2024
Pages: 54
Source title: Principles and Approaches to Diagnostic Bone Marrow Examination
Source Author(s)/Editor(s): Samia Hassan Rizk (Cairo University, Egypt)
DOI: 10.4018/978-1-6684-5818-1.ch012

Keywords: Medical Diagnosis and Practice / Medical Information Science Reference / Medical Treatment & Care / Medicine & Healthcare

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Abstract

Most mature B cell lymphomas arise as clonal expansions corresponding to differentiation pathway stages with few exceptions. Many immunologic, toxic, and genetic factors predispose to lymphoma development. B-cell lymphomas are the most frequent types, often widely disseminated, involving the bone marrow and hemopoietic system. Many reactive conditions simulate lymphomatous infiltrates and need special diagnostic consideration, including viral and immunological reactions. The diagnosis should integrate clinicopathologic features, imaging, comprehensive hematologic examination, immunophenotyping, cytogenetics, molecular profile, and risk stratification. This comprehensive assessment also helps with treatment selection and potential targeted therapy.

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Mature B Cell Lymphoproliferation and Lymphomas: Diagnostic Approach

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