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Myocardial Infarction: Disease Mechanisms and Therapeutic Perspectives
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Author(s): Kalyan C. Chapalamadugu (University of South Florida, USA), Samhitha Gudla (University of South Florida, USA), Rakesh Kukreja (Virginia Commonwealth University, USA)and Srinivas M. Tipparaju (University of South Florida, USA)
Copyright: 2017
Pages: 22
Source title:
Emerging Applications, Perspectives, and Discoveries in Cardiovascular Research
Source Author(s)/Editor(s): Ashim Malhotra (Pacific University, USA)and Shivani Soni (California State University, Fullerton, USA & Chapman University, USA & Alabama State University, USA)
DOI: 10.4018/978-1-5225-2092-4.ch008
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Abstract
Myocardial infarction (MI) is a major cardiovascular disease (CVD) and ranks among the leading causes of morbidity and mortality in humans, worldwide. Despite advances in disease prevention and treatment strategies, majority of the developed and developing world's suffer higher disease burden from MI, and incur billions of dollars in healthcare costs (Murray et al., 2015). Global estimates from 2013 show that MI is the major cardiovascular disease (CVD), and that deaths due to MI accounted for nearly half of the 17 million CVD mortalities (GBD, 2013; Mortality and Causes of Death Collaborators, 2015). Within the United States, MI top's the chart of both communicable and non-communicable diseases in terms of health loss that it is estimated to have inflicted in the population (Murray, et al., 2015). It has been estimated that every 2 minutes, three Americans suffer from myocardial infarction (MI), primary cause of MI being coronary blood flow obstruction and myocardial damage. The annual estimates of MI incidence in USA are approximately three quarter million a year while almost two-thirds of these cases represent new attacks (Mozaffarian, et al., 2015). Collectively, MI continues to lead the charts for CVD incidence rates, health loss, mortalities thereby putting enormous strain on healthcare system.
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