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Regulatory T Cell-Based Immunotherapy: Prospects of Antigen-Specific Tolerance Induction
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Author(s): Sonja Schallenberg (Center for Regenerative Therapies Dresden, Germany), Cathleen Petzold (Center for Regenerative Therapies Dresden, Germany), Julia Riewaldt (Center for Regenerative Therapies Dresden, Germany) and Karsten Kretschmer (Center for Regenerative Therapies Dresden, Germany)
Copyright: 2013
Pages: 25
Source title:
Medical Advancements in Aging and Regenerative Technologies: Clinical Tools and Applications
Source Author(s)/Editor(s): Andriani Daskalaki (Max Planck Institute for Molecular Genetics, Germany)
DOI: 10.4018/978-1-4666-2506-8.ch006
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Abstract
CD4+CD25+ regulatory T (Treg) cells expressing the forkhead box transcription factor Foxp3 have a vital function in the maintenance of immune homeostasis and the prevention of fatal multi-organ autoimmunity throughout life. In the last decade, Foxp3+ Treg cells have raised the hope for novel cell-based therapies to achieve tolerance in clinical settings of unwanted immune responses such as autoimmunity and graft rejection. Conceptually, the antigen-specific enhancement of Treg cell function is of particular importance because such strategies will minimize the requirements for pharmaceutical immunosuppression, sparing desired protective host immune responses to infectious and malignant insults. This chapter discusses current concepts of Treg cell-based immunotherapy with particular emphasis on antigen-specific Treg cell induction from conventional CD4+ T cells to deal with organ-specific autoimmunity.
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