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Role of Epigenetics in Cancer Genomics
Abstract
Epigenetics is the study of changes in organisms caused by modification of gene expression rather than alteration of the genetic code itself. ChIP-seq, is a method used to analyze protein interactions with DNA. It is a type of epigenetic analysis technique. Chromatin immunoprecipitation coupled with massive parallel sequencing (ChIP-seq) is gaining popularity day by day because of its clinical significance. It is a very effective tool in diagnosis of disease such as cancer. ChIP-seq is found to be very effective tool in understanding basic regulatory mechanism, cell differentiation study and studying disease processes with the decreasing cost of sequencing, ChIP-seq has become an indispensable tool for studying gene regulation and epigenetic mechanisms. The Present review explores epigenetic methods, pipeline and its role in cancer.
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