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Systems Biology of Human-Pathogenic Fungi
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Author(s): Daniela Albrecht (Leibniz Institute for Natural Product Research and Infection Biology -Hans-Knoell-Institute (HKI), Germany)and Reinhard Guthke (Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knoell-Institute (HKI), Germany)
Copyright: 2009
Pages: 19
Source title:
Handbook of Research on Systems Biology Applications in Medicine
Source Author(s)/Editor(s): Andriani Daskalaki (Max Planck Institute for Molecular Genetics, Germany)
DOI: 10.4018/978-1-60566-076-9.ch024
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Abstract
This chapter describes a holistic approach to understand the molecular biology and infection process of human-pathogenic fungi. It comprises the whole process of analyzing transcriptomic and proteomic data. Starting with biological background, information on Aspergillus fumigatus and Candida albicans, two of the most important fungal pathogens, is given. Afterwards, techniques to create transcriptome and proteome data are described. The chapter continues with explaining methods for data processing and analysis. It shows the need for, and problems with data integration, as well as the role of standards, ontologies, and databases. General aspects of these 3 major topics are explained and connected to the research on human-pathogenic fungi. Finally, the near future of this research topic is highlighted. This chapter aims to provide an overview on analyses of data from different cellular levels of human-pathogenic fungi. It describes their integration and application of systems biology methodologies.
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