The IRMA Community
Newsletters
Research IRM
Click a keyword to search titles using our InfoSci-OnDemand powered search:
|
Systems Biology Strategies in Studies of Energy Homeostasis In Vivo
|
|
Author(s): Matej Orešic (VTT Technical Research Centre of Finland, Finland)and Antonio Vidal-Puig (Institute of Metabolic Science, Addenbrooke’s Hospital, UK)
Copyright: 2009
Pages: 7
Source title:
Handbook of Research on Systems Biology Applications in Medicine
Source Author(s)/Editor(s): Andriani Daskalaki (Max Planck Institute for Molecular Genetics, Germany)
DOI: 10.4018/978-1-60566-076-9.ch021
Purchase
|
Abstract
In this chapter the authors report on their experience with the analysis and modeling of data obtained from studies of animal models related to obesity and metabolic syndrome. The complex interactions of genetic and environmental factors contributing to the failure of energy balance that lead to obesity, as well as tight systemic regulation to maintain energy homeostasis, require application of the systems biology strategy at the physiological level. In vivo systems offer the possibility of investigating not only the effects of specific genetic modifications or treatments in selected tissues and organs, but also to elucidate compensatory allostatic mechanisms induced to maintain the homeostasis of the whole system. A key challenge for systems biology is to characterize different systems’ responses in the context of activated pathways. One possible strategy is based on reconstruction of tissue specific pathways using lipidomics, or metabolomics in general, in combination with proteomic and transcriptomic profiles. This approach was applied to obese mouse model and revealed activation of multiple liver pathways that may lead to metabolic products, which may impair insulin sensitivity.
Related Content
|
David Edson Ribeiro, Valter Augusto de Freitas Barbosa, Clarisse Lins de Lima, Ricardo Emmanuel de Souza, Wellington Pinheiro dos Santos.
© 2021.
15 pages.
|
|
Juliana Carneiro Gomes, Maíra Araújo de Santana, Clarisse Lins de Lima, Ricardo Emmanuel de Souza, Wellington Pinheiro dos Santos.
© 2021.
12 pages.
|
|
Maíra Araújo de Santana, Jessiane Mônica Silva Pereira, Clarisse Lins de Lima, Maria Beatriz Jacinto de Almeida, José Filipe Silva de Andrade, Thifany Ketuli Silva de Souza, Rita de Cássia Fernandes de Lima, Wellington Pinheiro dos Santos.
© 2021.
19 pages.
|
|
Jessiane Mônica Silva Pereira, Maíra Araújo de Santana, Clarisse Lins de Lima, Rita de Cássia Fernandes de Lima, Sidney Marlon Lopes de Lima, Wellington Pinheiro dos Santos.
© 2021.
25 pages.
|
|
Adriel dos Santos Araujo, Roger Resmini, Maira Beatriz Hernandez Moran, Milena Henriques de Sousa Issa, Aura Conci.
© 2021.
35 pages.
|
|
Abir Baâzaoui, Walid Barhoumi.
© 2021.
21 pages.
|
|
Marcus Costa de Araújo, Luciete Alves Bezerra, Kamila Fernanda Ferreira da Cunha Queiroz, Nadja A. Espíndola, Ladjane Coelho dos Santos, Francisco George S. Santos, Rita de Cássia Fernandes de Lima.
© 2021.
44 pages.
|
|
|