The Development and Structure of the Bone Marrow Hematopoietic System

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Copyright: 2024
Pages: 30
Source title: Principles and Approaches to Diagnostic Bone Marrow Examination
Source Author(s)/Editor(s): Samia Hassan Rizk (Cairo University, Egypt)
DOI: 10.4018/978-1-6684-5818-1.ch001

Keywords: Medical Diagnosis and Practice / Medical Information Science Reference / Medical Treatment & Care / Medicine & Healthcare

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Abstract

The bone marrow is a complex, finely regulated system that widely extends in the body. It has unique development, microstructure, and functional characteristics that adapt to the flocculating body needs in steady-state and stress conditions. The bone marrow is an essential tissue for investigating most hematologic disorders. The study of the pathobiology of human bone marrow facilitates understanding many of its observed changes in benign and malignant conditions. This chapter explains the bone marrow development from the embryo to early infancy and throughout life, emphasizing the critical function-regulating features and the role of different cellular and humoral elements. The discussion of the concept and functions of the hemopoietic niches focuses on the maturation of different hemopoietic lineages within the bone marrow.

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