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The Diagnostic Approach to Bone Marrow Lymphoid Infiltrates
Abstract
The diagnosis of lymphoid infiltrates in the bone marrow may be challenging for many reasons. The bone marrow is not often the primary site for most lymphoproliferative neoplasms, except leukemic and precursor subtypes but is a frequent site for dissemination, sometimes with the primary tumor not clinically evident. In addition, the overlapping morphology, subtle infiltration, transformation, and mimicking reactive conditions are further challenges. The approach to bone marrow evaluation varies with the clinicopathologic context, notably a clinically suspected lymphoma or staging and follow-up of lymphoma diagnosed in lymph nodes or extranodal sites. In any of these conditions, the exclusion of mimicking reactive and benign conditions is essential.
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