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A Randomized Double-Blind Clinical Trial of Dexmedetomidine vs. Ketamine Postoperative Epidural Analgesia in Lower Limb Orthopedic Surgeries
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Author(s): Vithal K. Dhulkhed (Krishna Vishwa Vidyapeeth, India), P. B. Jamale (Krishna Institute of Medical Sciences, India), V. M. Joshi (Krishna Institute of Medical Sciences, India)and Abeer Alatawi (Tabuk University, Saudi Arabia)
Copyright: 2024
Pages: 12
Source title:
Advancements in Clinical Medicine
Source Author(s)/Editor(s): P. Paramasivan (Dhaanish Ahmed College of Engineering, India), S. Suman Rajest (Dhaanish Ahmed College of Engineering, India), Karthikeyan Chinnusamy (Veritas, USA), R. Regin (SRM Instıtute of Science and Technology, India)and Ferdin Joe John Joseph (Thai-Nichi Institute of Technology, Thailand)
DOI: 10.4018/979-8-3693-5946-4.ch012
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Abstract
Improving patient outcomes after lower limb orthopaedic procedures requires effective postsurgical pain management. This study compared the safety and analgesic effectiveness of dexmedetomidine and ketamine, two potentially effective treatments for postoperative pain management when given epidurally. A randomised controlled trial comprised one hundred patients aged eighteen to twenty undergoing lower limb orthopaedic treatments. Patients were divided into two groups, with Group 1 receiving epidural dexmedetomidine and Group 2 receiving epidural ketamine. The primary outcome was the amount of time until rescue analgesia was needed. Secondary outcomes included hemodynamic indicators, sedation levels, side effects, and the number of requests for rescue analgesia.
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