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Amyotrophic Lateral Sclerosis Involving Gliopathy: Insights Into the Underlying Mechanisms
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Author(s): Asmaa Haj-Khlifa (Faculty of Science Semlalia, Cadi Ayyad University, Morocco), Hafida El Ghachi (Faculty of Science Semlalia, Cadi Ayyad University, Morocco), Mjid Oukhrib (Faculty of Science Semlalia, Cadi Ayyad University, Morocco), Halima Gamrani (Laboratory of Neuroscience, Pharmacology and Environment, Faculty of Science Semlalia, Cadi Ayyad University, Morocco)and Moulay Mustapha Bouyatas (Polydisciplinary Faculty of Safi, Cadi Ayyad University, Morocco)
Copyright: 2024
Pages: 16
Source title:
Physiology and Function of Glial Cells in Health and Disease
Source Author(s)/Editor(s): Bilal El-Mansoury (Faculty of Sciences, Chouaib Doukkali University, Morocco), Omar El Hiba (Chouaib Doukkali University, Morocco)and Arumugam Radhakrishnan Jayakumar (University of Miami, USA)
DOI: 10.4018/978-1-6684-9675-6.ch010
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Abstract
Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease, causing death within two to five years following diagnosis. ALS is a disease characterized by motor neuron degeneration and destruction of the neuromuscular junction (NMJ). To date, numerous genetic mutations have been associated with ALS, but the mutation in the gene coding for superoxide dismutase (SOD1) has been the most extensively studied. Nevertheless, studies carried out on rodent models and ALS patients have shown that damage to glial cells contributes directly to the development and progression of the disease. However, few studies have focused on the properties of glial cells in ALS. The accumulation of knowledge on the active role and pathological mechanisms of each glial type in the disease must be carefully applied to better understand the ALS pathophysiology, but also for the development of targeted therapy for glial cells. Therefore, in this chapter the authors aimed to compile the most recent information on how each type of glial cell contributes to the development of ALS.
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