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Brain Aging and Glial Cells: What Is the Link?
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Author(s): Kamal Smimih (Faculty of Sciences and Techniques, Sultan Moulay Slimane University, Morocco), Chaima Azzouhri (Faculty of Sciences and Techniques, Sultan Moulay Slimane University, Morocco), Fatima Ez-Zahraa Saad (Independent Researcher, Morocco), Youssef Ait Hamdan (Higher Normal School, Cadi Ayyad University, Morocco), Jawad Laadraoui (Faculty of Sciences, Hassan II University of Casablanca, Casablanca, Morocco), Nadia Zouhairi (Faculty of Sciences and Techniques, Sultan Moulay Slimane University, Morocco)and Mohamed Merzouki (Faculty of Sciences and Techniques, Sultan Moulay Slimane University, Morocco)
Copyright: 2024
Pages: 17
Source title:
Physiology and Function of Glial Cells in Health and Disease
Source Author(s)/Editor(s): Bilal El-Mansoury (Faculty of Sciences, Chouaib Doukkali University, Morocco), Omar El Hiba (Chouaib Doukkali University, Morocco)and Arumugam Radhakrishnan Jayakumar (University of Miami, USA)
DOI: 10.4018/978-1-6684-9675-6.ch005
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Abstract
Brain aging is a complicated and diversified process that includes an ongoing decline in cognitive performance as well as various cellular and molecular changes in the brain. During an individual's life, glial cells such as oligodendrocytes, microglia, and astrocytes are crucial for maintaining healthy brain function. Astrocytes support neurons but may become less efficient with age, contributing to cognitive decline. Microglia, the brain's immune cells, can turn overactive with age, causing inflammation which can lead to neuronal damage. Oligodendrocytes, responsible for myelin sheath maintenance, also undergo changes, affecting neural communication. With advancing age, changes in glial cell function may lead to neuroinflammation, oxidative damage, and abnormalities in neural circuitry, all of which contribute to age related cognitive decline and neurodegenerative disorders. This chapter delves into the intricate dynamics of brain aging, focusing on the profound influence of age-related changes in glial cells.
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