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Astrocytes Reprogramming for Neurodegenerative Disease Management
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Author(s): Lahcen Tamegart (Abdelmalek Essaâdi University, Morocco), Rabii Hilali (Abdelmalek Essaâdi University, Morocco), Hajar Ouaki (Biology Department, Higher School of Teachers (ENS), Mohammed V University in Rabat, Morocco), Fatima Rachidi (Mohammed V University in Rabat, Morocco), Ibtissam Chakir (Sultan Moulay Slimane University, Morocco), Rabia Ajana (Abdelmalek Essaadi University, Morocco), Dia Eddine Oudghiri (Abdelmalek Essaadi University, Morocco), Ahmed Draoui (Cadi Ayyad University, Morocco), Mjid Oukhrib (Faculty of Sciences Semlalia, Cadi Ayyad University, Morocco), Hafida El Ghachi (Cadi Ayyad University, Morocco), Abdelali Ben Maloui (Cadi Ayyad University, Morocco), Abdelaati El Khiat (Independent Researcher, Morocco)and Halima Gamrani (Cadi Ayyad University, Morocco)
Copyright: 2024
Pages: 18
Source title:
Physiology and Function of Glial Cells in Health and Disease
Source Author(s)/Editor(s): Bilal El-Mansoury (Faculty of Sciences, Chouaib Doukkali University, Morocco), Omar El Hiba (Chouaib Doukkali University, Morocco)and Arumugam Radhakrishnan Jayakumar (University of Miami, USA)
DOI: 10.4018/978-1-6684-9675-6.ch016
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Abstract
Neurodegenerative disorders (NDD) are chronic conditions that lead to nerve cells degeneration in the central nervous system. The most common NDD are Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and Huntington's disease (HD). Parkinson's disease (PD) is recognized as the second most common neurodegenerative disease after Alzheimer's disease (AD) and Huntington disease (HD). Astrocytes reprogramming has been recently proposed as one of the most important treatments to stop the progression of these neurological diseases. By targeting the microRNA, astrocytes in the animal brain could be reprogrammed into various functional neural systems. Activation of endogenous genes could be a revolutionary therapeutic approach for treating neurological diseases. Reprogrammed astrocytes could also be used to generate various types of neurons lost in case of Huntington's disease, Parkinson's disease, and Alzheimer's disease. The ability to reprogram astrocytes into functional neurons was classified as a new advancement for PD, AD, and HD treatments.
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