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Estimating Biosafety of Biodegradable Biomedical Materials From In Vitro Ion Tolerance Parameters and Toxicity of Nanomaterials in Brain
Abstract
Ensuring human health safety necessitates rigorous biosafety evaluations of substances and materials, particularly in the context of in-vivo exposure. Biodegradable materials, known for their natural decomposition capabilities through biological mechanisms, may exhibit toxicological profiles differing from non-biodegradable substances. Prior to their application in medical devices such as stents and implants, it is imperative to conduct thorough testing to ascertain their safety. This chapter aims to provide a comprehensive assessment of the in-vivo biosafety of various biodegradable materials. The authors employ an integrative approach, combining in-vitro ion-tolerance assays with in-vivo microanalysis techniques. This dual methodology allows for a detailed evaluation of the materials' biocompatibility and potential toxicity, particularly focusing on nanomaterial-induced toxicity in neural tissues. These findings offer critical insights into the safe application of biodegradable biomedical materials, underpinning informed decision-making in their usage for medical applications.
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