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Extra-Pulmonary TB: Changing Paradigm in Diagnosis

Extra-Pulmonary TB: Changing Paradigm in Diagnosis
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Author(s): Sarita Rani (Central University of Rajasthan, India), Ankur Kaul (Institute of Nuclear Medicine and Allied Sciences, India), Anil Kumar Mishra (Institute of Nuclear Medicine and Allied Sciences, India)and Umesh Gupta (Central University of Rajasthan, India)
Copyright: 2021
Pages: 26
Source title: Strategies to Overcome Superbug Invasions: Emerging Research and Opportunities
Source Author(s)/Editor(s): Dimple Sethi Chopra (Punjabi University, India)and Ankur Kaul (Institute of Nuclear Medicine and Allied Sciences, India)
DOI: 10.4018/978-1-7998-0307-2.ch005


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Tuberculosis is considered a fatal respiratory disease commonly seen in developing countries. This chapter includes the global scenario of TB patients and brief description of TB history, its pathogenesis, types, diagnosis tests, emergence of MDR (multi drug resistance) and XDR (extensively drug resistance). The traditional chemotherapy of TB includes first and second line drug therapy. These lines of therapies face many difficulties such as low solubility, low bioavailability, and stability issues. Therefore, some new drugs were introduced in the market that showed effective results to the patients. Nanoparticulate drug delivery gained much focus in recent years due to its advantages and ideal characteristics. Numerous nanoparticles, liposomal formulations, and polymeric micelles were reported by the researchers with significant and considerable results. Inhalable formulations were also prepared by scientists that showed effective and remarkable anti-tuberculosis action on TB patients. Many efforts are awaited to completely eradicate TB from the planet.

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