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Nanotechnology Applications in Cardiology: Proof of Principle
Abstract
Nanotechnology studies particles and fibers in the 10e-9 m dimensional range. Multiple advancements, availability of materials, manufacturing and process technology, and improvements in targeted-delivery capabilities have dramatically impacted the use of nanotechnology in medical science. However, nowhere has the benefit been as profound as in the field of cardiology. This chapter discusses various aspects of the use of nanotechnology, including materials, design, and formulation characteristics. The authors begin by introducing the complexity of cardiovascular disease, identifying the problem of scale, and of targeted delivery, followed by a brief history of nanotechnology. Specific instances of innovation milestones, such as the invention of Drug Eluting Stents are followed by a detailed discussion of materials and a proposed classification scheme. Nanotechnology-based cardiovascular imaging systems for use in diagnostic and preventive medicine and scaffolds for the design of 3D artificial constructs as putative futuristic replacements of transplant hearts are discussed in detail.
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