The IRMA Community
Newsletters
Research IRM
Click a keyword to search titles using our InfoSci-OnDemand powered search:
|
Oligodendrogliopathy in Multiple Sclerosis
|
Author(s): Abdelali Ben Maloui (Faculty of Sciences Semlalia, Cadi Ayyad University, Morocco), Lahcen Tamegart (Abdelmalek Essaadi University, Morocco), Mjid Oukhrib (Cadi Ayyad University, Morocco), Hafida El Ghachi (Faculty of Sciences Semlalia, Cadi Ayyad University, Morocco), Youssef Ait Hamdan (Cadi Ayyad University, Morocco), Rachid Soulimani (Lorraine University, France)and Halima Gamrani (Cadi Ayyad University, Morocco)
Copyright: 2024
Pages: 18
Source title:
Physiology and Function of Glial Cells in Health and Disease
Source Author(s)/Editor(s): Bilal El-Mansoury (Faculty of Sciences, Chouaib Doukkali University, Morocco), Omar El Hiba (Chouaib Doukkali University, Morocco)and Arumugam Radhakrishnan Jayakumar (University of Miami, USA)
DOI: 10.4018/978-1-6684-9675-6.ch011
Purchase
|
Abstract
Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system (CNS), which is characterized by demyelination and neurodegeneration. Oligodendrocytes have an essential role in maintaining the integrity of myelin, the protective sheath that surrounds nerve fibers and is indispensable for efficient signal transmission. Nevertheless, in multiple sclerosis, oligodendrocytes become dysfunctional, leading to myelin deterioration and axonal degeneration. Recent research suggests that metabolic changes, including mitochondrial dysfunction and alterations in glucose and lipid metabolism, contribute significantly to the pathogenesis of MS. Mitochondrial dysfunction is observed in both immune cells and CNS oligodendrocytes of MS patients. Impaired mitochondrial function leads to energy deficits, affecting crucial processes such as impulse transmission and axonal transport, ultimately contributing to neurodegeneration. Understanding the complex relationship between these mechanisms is crucial to the development of an effective treatment for MS.
Related Content
Kamal Smimih, Bilal El-Mansoury, Chaima Azzouhri, Youssef Ait Hamdan, Fatima Ez-zahraa Saad, Merzouki Mohamed.
© 2024.
19 pages.
|
Fatima Ez-Zahraa Saad, Kamal Smimih, Abdelali Bitar, Manal Khanouchi.
© 2024.
12 pages.
|
Samira Boulbaroud, Hanane Khalki, Fatima Zahra Azzaoui.
© 2024.
28 pages.
|
Bilal El-Mansoury, Kamal Smimih, Youssef Ait Hamdan, Ahmed Draoui, Samira Boulbaroud, Arumugam Radhakrishnan Jayakumar.
© 2024.
23 pages.
|
Kamal Smimih, Chaima Azzouhri, Fatima Ez-Zahraa Saad, Youssef Ait Hamdan, Jawad Laadraoui, Nadia Zouhairi, Mohamed Merzouki.
© 2024.
17 pages.
|
Himel Mondal, Shaikat Mondal.
© 2024.
20 pages.
|
Hafida El Ghachi, Asmaa Haj-khlifa, Mjid Oukhrib, Lahcen Tamegart, Youssef Ait Hamdan, Abdelali Ben Maloui, Najib Kissani, Halima Gamrani.
© 2024.
25 pages.
|
|
|